Tingible body macrophage, lymphoid follicle, H/E x100
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The tingible body macrophage (center), seen in most lymphoid follicles, is the quintessential antigen presenting cell. The macrophage processes particulate antigens (represented by the tingible bodies seen in cytoplasmic endosomes) and processes them for presentation to surrounding T-cells, in association with MHC molecules. If a T-cell is available to respond to that particular antigen, then clonal expansion can occur.